Detalhe da pesquisa
1.
Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy.
Biochemistry
; 58(35): 3700-3710, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31403283
2.
Prototyping kinase inhibitor-cytotoxin anticancer mutual prodrugs activated by tumour hypoxia: A chemical proof of concept study.
Bioorg Med Chem Lett
; 29(10): 1215-1219, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30885680
3.
Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence.
J Biol Chem
; 288(52): 37138-53, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24196959
4.
Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.
Org Biomol Chem
; 12(21): 3386-92, 2014 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24737463
5.
FSL-61 is a 6-nitroquinolone fluorogenic probe for one-electron reductases in hypoxic cells.
Biochem J
; 452(1): 79-86, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23480813
6.
Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia.
Chin J Cancer
; 33(2): 80-6, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23845143
7.
Pseudomonas aeruginosa NfsB and nitro-CBI-DEI--a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy.
Mol Cancer
; 12: 58, 2013 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23758947
8.
Synthesis and cytotoxicity of pyranonaphthoquinone natural product analogues under bioreductive conditions.
Bioorg Med Chem
; 21(24): 7971-80, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24436995
9.
Design and Biological Evaluation of Piperazine-Bearing Nitrobenzamide Hypoxia/GDEPT Prodrugs: The Discovery of CP-506.
ACS Med Chem Lett
; 14(11): 1517-1523, 2023 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37974941
10.
Diflavin oxidoreductases activate the bioreductive prodrug PR-104A under hypoxia.
Mol Pharmacol
; 81(1): 31-40, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21984255
11.
Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours.
Cancer Gene Ther
; 29(2): 178-188, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33558701
12.
Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications.
Pharmaceuticals (Basel)
; 15(2)2022 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35215297
13.
Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3.
Pharmaceuticals (Basel)
; 14(12)2021 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34959631
14.
Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506.
Mol Cancer Ther
; 20(12): 2372-2383, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34625504
15.
Steady-state and stopped-flow kinetic studies of three Escherichia coli NfsB mutants with enhanced activity for the prodrug CB1954.
Biochemistry
; 48(32): 7665-72, 2009 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-19580253
16.
Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials.
Clin Transl Radiat Oncol
; 15: 62-69, 2019 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-30734002
17.
2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors.
ACS Med Chem Lett
; 8(5): 543-548, 2017 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28523108
18.
Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy.
Cell Chem Biol
; 24(3): 391-403, 2017 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28262557
19.
2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors.
Eur J Med Chem
; 135: 531-543, 2017 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28521156
20.
Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress.
Cancers (Basel)
; 8(7)2016 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27367731